The integrated high-quality development of the Yangtze River Delta (YRD) is of great importance for the long-term development and stability of China's economy. In order to scientifically and comprehensively understand the problems existing in the development of the YRD in the New Era and clarify the future development path, experts from different fields are invited to discuss the regional coordination, industrial coordination, and transportation organization. Interviews were conducted on research frontiers such as urban system evolution, cross-regional cooperation, factor allocation, river basin planning, integration paths, and green and low-carbon development. The interview results show that the YRD is the region with the most active economic development, the highest degree of openness and the strongest innovation ability in China. But it is still characterized by prominent problems, such as unbalanced internal development, fragmented inter-regional traffic, remaining administrative barriers, unsound river basin ecological cooperation, insufficient coordinated industrial development and weak green economic system. The strategic position of the study area in the development of China and the world requires the integration of theoretical knowledge of various disciplines and subjects, and continuous attention to the major scientific proposition of the integrated high-quality development of the delta region from different perspectives. Closely related to "integration" and "high quality", the integration of the YRD should first innovate the mechanism to narrow the development differences within the region, strengthen the basic support for comprehensive transportation integration, and break through the constraints of administrative boundaries. Secondly, to innovate the mechanism and system to ensure the effective flow and allocation of production factors, through the integration and development of the value chain, industrial chain, and innovation chain to consolidate the integration; again, to promote the centralized use of land elements in the YRD, improve the land carrying capacity of the YRD, and integrate the whole delta region. High-quality development provides sufficient land element guarantee. Thus, it is necessary to optimize the spatial structure of population and employment, strengthen inter-city environmental pollution prevention and control, advance inter-provincial coordination and cooperation in major river basins, improve the ecosystem services function and promote green integrated development in the YRD. Finally, we should develop new concepts, achieve low-carbon development through scientific research breakthroughs and market mechanisms, and build a world-class hub of flow space under the guidance of the national innovation-driven strategy, so as to create a new situation in the high-quality integration of the YRD region. The above viewpoints provide scientific and feasible theoretical and decision support for the integrated high-quality development of the YRD.