Landscape pattern change has received much attention in recent years, since they provide key information of the effects of human activities on landscape. Most of past works mainly focused on the whole landscape pattern rather than the internal variation of the landscape. Meanwhile, lots of studies are about urban area, watershed, forest and wetland, while few have been done on the coast. In China, works about landscape change in the Liaohe River Delta, the Yellow River delta and the Zhujiang River Delta have been conducted at the county scale, and some works have been done concerning the features of coastal landscape at the national scale. To investigate the impact of reclamation on the landscape pattern of coastal wetlands, in this paper, Yancheng National Natural Reserve (from Xinyang Port to Simaoyou River) was chosen as the study area. This area was divided into two parts: unreclaimed (from Xinyang Port to Doulong Port) and reclaimed (from Doulong Port to Simaoyou River) zones. Supported by RS, GIS and FRAGSTATS technologies, using remote sensing data from 1984 to 2013 as basic information resource, the impacts of reclamation on the change of coastal wetland landscape pattern and the displacement of patches' centroids were analyzed. The results indicated that: 1) In unreclaimed zones, the natural landscape remained dominant in the landscape structure, taking 84.6% of the area in 2013. From 1984 to 2013, the wetland of Pragmites communis and Spartina spp. increased by 4770.6 hm2 and 4202.8 hm2 respectively, while the wetland of Saueda spp. decreased by 2656.7 hm2. In reclaimed zones, massive original natural landscape converted to artificial landscape types during 1984-2013, and the artificial landscape held dominant position in the landscape structure since 2000. The natural vegetation area continuously decreased except Spartina spp., while the aquaculture pond area increased rapidly, reaching 60.5% of the area in 2013. 2) In unreclaimed zones, the landscape fragmentation remained at low level (from 0.27 to 0.28) after 1995, while the shape of patches trended to be complex and irregular. And the landscape diversity increased by 0.19 from 1984 to 2013. On the contrary, in reclaimed zones, the landscape fragmentation had a significant increase of 0.27 during 1984-2013, while the patches' shape trended to be simple and regular, and the landscape diversity decreased by 0.26. 3) In unreclaimed zones, the main driving factor of landscape pattern change was natural forces, and the centroids of landscape types moved continuously and keep the same direction. Conversely, because of the intervention of human activities, the movement of landscape type centroids in reclamation zones was disordered, variable and intricate.