Nowadays, with the increasingly coordinated development of regions, the study of population urbanization also urgently needs to be carried out from a broad regional perspective. Focusing on the three core issues of new urbanization, mamely, people, land, and property, the social, spatial, and economic attributes on population mobility are derived. Based on a comparison of the advantages and disadvantages of commonly used data methods in urbanization analysis, this paper constructs a new conceptual model for population urbanization in different scales with multi-source data. Using the census and survey data, mobile phone data, and enterprise registration data, the conceptual model is applied to an empirical study of urban dense areas-Yangzhou city and shows strong applicability, based on migration flow analysis, location identification, and enterprise headquarters-branch network analysis methods. The results show that: (1) At the regional level, due to the factors such as the threshold of settlement, family rights, and social security, population mobility is more cautious than capital flows. And it is compliant with the administrative district economy and urban hierarchy system. (2) At the municipal level, because the central city has greater advantages than the villages and towns, in terms of public service facilities and income levels, the urbanization form is mainly manifested in the direct connection between urban and rural areas, while the radiating and absorbing effects of key towns for population and enterprises are not strong. (3) In the era of ecological civilization, places with beautiful scenery, profound history, and rich cultural heritage are the natural soil for new economy. And the new economy has become a powerful engine for new urbanization in the late-developing areas. Yangzhou has a pleasant ecological environment and profound cultural atmosphere, which is the natural advantage and foundation of developing new types of economy. It needs to develop industrial platform, innovative environment, and innovation system to jointly create a comprehensive advantage of new economic development. Empirical research shows that the conceptual model has good applicability. It can identify the main pattern of economic and social linkages scientifically, reveal the intensive communicating area in town cluster region, and play a supporting role in delimiting urban development boundaries and optimizing the spatial pattern of land. Therefore, this model has a strong reference value for the study of regional coordination of territorial spatial plan at city and county level.