The paper analyzes the main problems related to resource and env ir onment in the ar-eas of The Bohai Sea Rimland,Yangtze River Delta and Pearl R iver Delta through a com parative method.The regional differentiation character s that the water resource shortage is getting more se-rious from south to north ,the farm resource waste is getting worse from north to south and envi-ronment al pollution is increasing together with the development of regional economy i n the east-ern coastal areas in China are put forward.Then,the interactive r elationship between the regional economic development and resource-environment especially in the industrialization period is dis-cussed and the interaction mode between the two parts has been revised and sum med up.Finally,according to the specific reality in our country,it proposes some countermeasures on ho w to har-monize the relationship between the economic development and resource environment as follows.One is to set up an industrial system which is benefic ial to the environment.The other is to strengthen the resource-environment ma nagement regulation.