At first, a multitemporal urban land use information is extracted from the Landsat images of Guiyang in 1947, 1973, 1990, 2001, 2006 and 2010 using multiple source data including historical literature, thematic maps and Landsat images, in which the spatiotemporal feature of urban expansion is analyzed after 1279. These characteristics involve expansion trend, direction, expansion intensity, scale and spatial differentiation and so on. The results show that: 1) before 1947, the main expanding directions were the south (Huaxi) and the west (Jinyang), and the main type was sprawling outwards, the velocity of urban expansion was slow. 2) The urban expansion of Guiyang filled in a small basin region from 1947 to 1973 and started an expansion out along the valley topography. The urban expansion showed a diffusion trend outward in the main urban region after 1990. 3) The expansion of urban fringe of Guiyang was arrived to the south (Huaxi), the east (Longdongbao), the northeast (Xintianzhai) and the west (Jinyang). Urban expansion of Guiyang after 2006 showed a significant Y-shaped pattern. At last, current rapid expansion of Guiyang is not suitable to the local sustainable development, Guiyang city is suggested stopping such rapid spatial expansion.