River system network is not only the water carrier, but also a medium between human and water, whose effect on human-water relationship is mainly reflected in the connectivity. If the factor of connectivity changes, the relationship between human and water will also change. It is urgent and critical to analyze and research on the changes of human-water relationship under the interconnected river system network. Based on the systematical summary of connectivity conditions and typical connectivity projects, this paper takes Zhengzhou City as the study area, analyzes the human-water relationship and obtains changes in relationships between human and water in Zhengzhou City under the context of interconnected river system network with the comparison of human-water relationship in different periods. This paper also summarizes the changing law and the trend of human-water relationship, and further, it reveals intrinsic links between the evolution of interconnected river system network and the changes of human-water relationship, which provides a reference for further regulating of human-water relationship and achieving human-water harmony.