At present, China's territory spatial planning attempts from top to bottom to resolve or relieve the key issues from macro level as far as possible which has arisen since the reform and opening-up such as the ecological environment, resources restriction, the conflict of man-land relationship, multiple management and the authority of spatial plans. Although China's territory spatial planning system, organization framework and technical regulation have so far formed relatively reasonable "universality" norms, at the strategic level, the discussion of regional "individuality" issues in the context of national security is still lacking. Facing the needs of the country and the special situation of Western China, we should establish a cross- province and cross-basin territory spatial planning of this region based on national security strategies. To ensure national security, territory spatial planning of Western China at the strategic level should focus on the following: (1) In theory, based on the perspective of national security, we proposed to construct the cross-province and cross-basin territory spatial planning of Western China. (2) In practice, we recommend formulating the "territory spatial planning of Western China-ecological security" of specialized national territory spatial planning which takes ecological zone, nature reserve as the core in spatial scale. What's more, based on the border and support line, we should carry out "territory spatial planning of Western China-survival security" of specialized national territory spatial planning, or determine the detailed rules and regulations of national defense security in spatial planning. In addition, taking the urban system as the organizational context, we should set up "territory spatial planning of Western China-life security" of specialized national territory spatial planning which is relying on main transportation lines, or determine the detailed rules and regulations of the harmonious society construction in Western China. Besides, following the divisions of the Main Functional Areas, we should formulate "territory spatial planning of Western China-production security" of specialized national territory spatial planning which is focusing on the regional central city and urban agglomeration, or determine the high-quality economic development in the western region. We should also restructure the ecological space, survivable space, living space and production space. (3) In particular, we recommended strengthening the construction of border towns or villages, and establishing the "sanxian" (three lines) construction in the New Era, "the key construction belt around the Qinghai-Tibet Plateau" in the western region, which can meet the national security needs of limited globalization and achieve "dual circulation pattern" in the post-epidemic period. On the whole, the territory spatial planning of Western China should be different from that of the eastern and central regions. We should not impose uniformity on the implementation of the policies.