The world is undergoing tremendous changes, and food security is encountering major challenges in China and even the world. In order to systematically study globalization and explore its new patterns, new issues and new paths for food security, we interviewed ten distinguished professors from different fields and discussed hot topics, including the potential for increasing farmland production, agricultural water and soil resources and food production, food waste, international agricultural product trade, stable supply of key agricultural product, global agricultural food system, dual circulation pattern and corporate actions, global food production and consumption, international food security governance, and cutting-edge research on food safety. The result shows that the global agricultural food system has entered an era of complexity and high risk. International food security governance is facing challenges in terms of resources, binding force and action power. We are facing an increasing pressure of import dependent agricultural products to ensure stable supply. It is necessary to deepen supply-side reform and strengthen demand-side management so as to guarantee national food security. New changes have taken place in globalization. This will test China's ability to deepen agricultural opening-up, participate in global food security governance, and achieve national food security. In the face of complex international and domestic situations, for better national food security governance, it is necessary to adhere to system thinking and coordinate domestic and international markets. It is also very important to target the entire industry chain, emphasize risk control, and handle the relationship between the government and the market. Furthermore, researchers need to explore the internal relationships and specific mechanisms between food security and other important issues, such as food systems, ecosystems, high-quality development goals, agricultural opening-up, and new dual-circulation development patterns. This could provide a scientific reference for establishing and improving the national food security strategy of "featuring self-sufficiency based on domestic grain production, guaranteed food production capacity, moderate imports, and technological support" in the New Era.