Abstract: Lake is regarded as a"evaporating dish"in the arid area. It is an indicator and very sensitive to the regional eco-environmental change. The variation of lake water resources objectively records the process of regional hydrologic change effects by climate change and human activities. This reflected the water balance in a basin. So, timely and accurately get lake water resources change information (e.g. lake area, lake level and water volume) is very important for understanding regional and global environmental change. And that will be useful to regional water resources management, planning and policy development. To further understand the lake spatio-temporal changes process in arid area under the background of global warming, this paper selected the largest inland freshwater lake (the Bosten Lake) in arid China as study area, and used multi- source remote sensing data, macroscopically, dynamically and continuously monitored the Bosten Lake area, water level and capacity change information in recent 40 years. Firstly, through the Landsat and CBERS satellite imagery, we extracted the lake area information since 1972. And then, the lake level information was retrieved from the ICESat/ GLAS laser point data. Thirdly, the water volume is calculated by the water level and the lake basin DEM data. Fourthly, the Bosten Lake"area- level- volume"relationship model is constructed. Finally, through the"area-level-volume"relationship model, we digitally reconstructed the change process of the Bosten hydrologic information in the nearly 40 years. On that basis, we analyzed the characteristics of the Bosten hydrologic information spatio-temporal changes from the aspect of water level, lake area and water volume and explored the driving force of the lake water resource changes. The results show that: the change tendency of the Bosten Lake water resources is in diminishing on the whole. But different historical periods have different change characteristics. The whole change process can be divided into three stages. 1) The year 1972- 1990 is the Bosten Lake shrinking stage. In this stage, lake area shrank, water level dropped and water volume reduced steadily. In year 1990, the decreasing reached the bottom, the lowest water level is 1045.32 m and the minimum lake area is 908.12 km². 2) The year 1990-2002 is the Bosten Lake significant expansion stage. In this stage, the Bosten Lake experienced water level rise, area expansion and the amount of lake water storage increased. In 2000, it reached the peak. The largest area is 1210.68 km², the highest level is 1048.5 m, the biggest water storage is about 90×10⁸ m³. 3) The year 2002-2010 is the Bosten Lake shrinking stage. Since 2002, the lake area, water level and water storage present continuous downward trend. Compared with 2002 and 2009, the lake water level declined 3.3 m and water quantity reduced 38.56%. That is the result of supply balance of regional water resources. The driving force of lake resource changes is not only climate fluctuations, but also human activities. In the short term, human activities are the mainly affecting factors of the Bosten water resource change. And the human activities interference is growing.