Abstract: In recent years, “Transferring from double cropping to single cropping” has become a great concern in academia, as it has linkages with intensive utilization of cultivated land and food security. By using panel data, the drivers and determinants that change double cropping to single cropping can be explained, and the result will help the policy-makers to formulate better targeted agricultural policy. This paper analyzes the change of cropping system in 2006-2011 based on household survey and land plot survey in an agro-pastoral interlaced region of the upper reaches of Dadu River watershed, and explores its influencing factors by adopting linear regression model. Results show that: 1) From 2006 to 2011, the area of corn planting was stable, the area of wheat planting dropped sharply, the area of potato planting rose fast and that of economic crops planting increased slowly. Moreover, crop arrangement tended to be diversified and the multiple-crop index reduced obviously. 2) Changes of non-agricultural income, change of livestock income, average area of plots and location variables are the main causes for the transfer of cropping system. The increase of non-agricultural income have positive effect on the transfer from double cropping to single cropping, while the increase of livestock income and average area of plots prevent this kind of transfer.