Abstract: Cities in China face high and rapidly increasing exposure to disaster risk, calling for effective countermeasures. Disasters occur only when hazards meet vulnerability; it is difficult to control the hazards, especially the natural hazards under current technology conditions, reducing disaster vulnerability is the most direct and effective way to reduce disaster risk, which requires first and foremost the identification and assessment of vulnerabilities of societies, economies, etc. Economic vulnerability assessment is a significant step in risk assessment, a prerequisite for effective disaster prevention planning and an important base for emergency management and recovery plan. Strong variation in economic vulnerability by location calls for microanalytic study which can provide useful and practical information for prevention planning, crisis management and recovery plan, therefore we choose block as the basic spatial unit. This paper developed a model for the economic vulnerability assessment, which is composed of the scale of enterprises, the vulnerability and importance of industrial sectors and economic density, accordingly, this paper conducts a case study of Haidian District in Beijing, the results show that the overall economic vulnerability of Haidian District is relatively low, 103 out of 647 blocks which account for only 4.91% of the area of Haidian District are at the level of high and very high economic vulnerability, however, these regions spatially agglomerate and have been the agglomeration areas of high-tech industries, commercial services, exhibition services, medical services, and the government services, all of which play an important part in Haidian's economy as well as Beijing's, therefore, we suggest that more attention should be paid to these regions in disaster risk management.